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1

Emerging principles in protease-based drug discovery

Drag, Marcin, Salvesen, Guy S.

Journal:

Nature Reviews Drug Discovery

Year:

2010

Language:

english

File:

PDF, 476 KB

english, 2010

2

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

Oberst, Andrew, Dillon, Christopher P., Weinlich, Ricardo, McCormick, Laura L., Fitzgerald, Patrick, Pop, Cristina, Hakem, Razq, Salvesen, Guy S., Green, Douglas R.

Journal:

Year:

2011

Language:

english

File:

PDF, 403 KB

english, 2011

3

The apoptosome: signalling platform of cell death

Riedl, Stefan J., Salvesen, Guy S.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2007

Language:

english

File:

PDF, 679 KB

english, 2007

4

Human ICE/CED-3 Protease Nomenclature

Emad S Alnemri, David J Livingston, Donald W Nicholson, Guy Salvesen, Nancy A Thornberry, Winnie W Wong, Junying Yuan

Journal:

Year:

1996

Language:

english

File:

PDF, 90 KB

english, 1996

5

Expedient Synthesis of Highly Potent Antagonists of Inhibitor of Apoptosis Proteins (IAPs) with Unique Selectivity for ML-IAP

Vamos, Mitchell, Welsh, Kate, Finlay, Darren, Lee, Pooi San, Mace, Peter D., Snipas, Scott J., Gonzalez, Monica L., Ganji, Santhi Reddy, Ardecky, Robert J., Riedl, Stefan J., Salvesen, Guy S., Vuori,

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 561 KB

english, 2013

6

Regulated Cell Death: Signaling and Mechanisms

Ashkenazi, Avi, Salvesen, Guy

Journal:

Annual Review of Cell and Developmental Biology

Year:

2014

Language:

english

File:

PDF, 1.17 MB

english, 2014

7

Regulating Cysteine Protease Activity: Essential Role of Protease Inhibitors As Guardians and Regulators

Turk, Boris, Turk, Dusan, Salvesen, Guy

Journal:

Current Pharmaceutical Design

Year:

2002

Language:

english

File:

PDF, 160 KB

english, 2002

8

Small Molecule Active Site Directed Tools for Studying Human Caspases

Poreba, Marcin, Szalek, Aleksandra, Kasperkiewicz, Paulina, Rut, Wioletta, Salvesen, Guy S., Drag, Marcin

Journal:

Chemical Reviews

Year:

2015

Language:

english

File:

PDF, 24.87 MB

english, 2015

9

A toolbox of fluorescent probes for parallel imaging reveals uneven location of serine proteases in neutrophils

Kasperkiewicz, Paulina, Altman, Yoav, D'Angelo, Maximiliano, Salvesen, Guy S., Drag, Marcin

Journal:

Journal of the American Chemical Society

Year:

2017

Language:

english

File:

PDF, 11.43 MB

english, 2017

10

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

Gonzalez Ramirez, Monica L, Poreba, Marcin, Snipas, Scott J, Groborz, Katarzyna, Drag, Marcin, Salvesen, Guy S

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 1.05 MB

english, 2018

11

Glycine Fluoromethylketones as SENP-Specific Activity Based Probes

Dr. Cristian Dobrotă, Domenico Fasci, Dr. Niculina D. Hădade, Dr. Gheorghe-Doru Roiban, Dr. Cristina Pop, Dr. Veronika M. Meier, Ioana Dumitru, Dr. Mihaela Matache, Dr. Guy S. Salvesen, Dr. Daniel P.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

12

Aza-Peptide Epoxides: A New Class of Inhibitors Selective for Clan CD Cysteine Proteases

Juliana L. Asgian, Karen Ellis James, Zhao Zhao Li, Wendy Carter, Alan J. Barrett, Jowita Mikolajczyk, Guy S. Salvesen, James C. Powers

Journal:

Year:

2003

File:

PDF, 76 KB

2003

13

Caspases: Keys in the Ignition of Cell Death

Jean-Bernard Denault, Guy S. Salvesen

Journal:

Year:

2003

File:

PDF, 50 KB

2003

14

ChemInform Abstract: Identification of Very Potent Inhibitor of Human Aminopeptidase N (CD13).

Renata Grzywa, Jozef Oleksyszyn, Guy S. Salvesen, Marcin Drag

Journal:

Year:

2010

File:

PDF, 18 KB

2010

15

DeSUMOylating enzymes—SENPs

Marcin Drag, Guy S. Salvesen

Journal:

Year:

2008

Language:

english

File:

PDF, 363 KB

english, 2008

16

Caspases on the brain

Carol M. Troy, Guy S. Salvesen

Journal:

Journal of Neuroscience Research

Year:

2002

Language:

english

File:

PDF, 115 KB

english, 2002

17

Identification of very potent inhibitor of human aminopeptidase N (CD13)

Renata Grzywa, Józef Oleksyszyn, Guy S. Salvesen, Marcin Drąg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 205 KB

english, 2010

18

Identification and Evaluation of Small Molecule Pan-Caspase Inhibitors in Huntington's Disease Models

Melissa J. Leyva, Francesco DeGiacomo, Linda S. Kaltenbach, Jennifer Holcomb, Ningzhe Zhang, Juliette Gafni, Hyunsun Park, Donald C. Lo, Guy S. Salvesen, Lisa M. Ellerby, Jonathan A. Ellman

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 1.18 MB

english, 2010

19

Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases

Victoria E. Albrow, Elizabeth L. Ponder, Domenico Fasci, Miklós Békés, Edgar Deu, Guy S. Salvesen, Matthew Bogyo

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

20

Kennedy's Disease : Caspase Cleavage of the Androgen Receptor Is a Crucial Event in Cytotoxicity

Lisa M. Ellerby, Abigail S. Hackam, Stephanie S. Propp, H. Michael Ellerby, Shahrooz Rabizadeh, Neil R. Cashman, Mark A. Trifiro, Leonard Pinsky, Cheryl L. Wellington, Guy S. Salvesen, Michael R. Hayd

Journal:

Journal of Neurochemistry

Year:

1999

Language:

english

File:

PDF, 295 KB

english, 1999

21

Interaction of subtilisins with serpins

Tomoko Komiyama, Hanne Grøn, Guy S. Salvesen, Philip A. Pemberton

Journal:

Protein Science

Year:

1996

Language:

english

File:

PDF, 3.17 MB

english, 1996

22

Serpin α1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy

Henryk Koloczek, Agnieszka Banbula, Jan Potempa, Guy S. Salvesen

Journal:

Protein Science

Year:

1996

Language:

english

File:

PDF, 3.68 MB

english, 1996

23

Nicotinamide Rescues Human Embryonic Stem Cell-Derived Neuroectoderm from Parthanatic Cell Death

Flavio Cimadamore, Carol Lynn Curchoe, Nazilla Alderson, Fiona Scott, Guy Salvesen, Alexey V. Terskikh

Journal:

Year:

2009

Language:

english

File:

PDF, 819 KB

english, 2009

24

Targeting activated integrin αvβ3 with patient-derived antibodies impacts late-stage multiorgan metastasis

Karin Staflin, Joseph S. Krueger, Janna Hachmann, Jane S. Forsyth, Mihaela Lorger, Sebastian C. J. Steiniger, Jenny Mee, Cristina Pop, Guy S. Salvesen, Kim D. Janda, Brunhilde Felding-Habermann

Journal:

Clinical and Experimental Metastasis

Year:

2010

Language:

english

File:

PDF, 1.01 MB

english, 2010

25

Programmed cell death and the caspases

GUY S. SALVESEN

Journal:

Year:

1999

Language:

english

File:

PDF, 781 KB

english, 1999

26

10.1038/27441

Bredesen, Dale E., Mehlen, Patrick, Rabizadeh, Shahrooz, Snipas, Scott J., Assa-Munt, Nuria, Salvesen, Guy S.

Journal:

Year:

1998

Language:

english

File:

PDF, 386 KB

english, 1998

27

10.1038/40901

Reed, John C., Deveraux, Quinn L., Takahashi, Ryosuke, Salvesen, Guy S.

Journal:

Year:

1997

Language:

english

File:

PDF, 437 KB

english, 1997

28

10.1038/74656

Koo, Edward H., Bredesen, Dale E., Lu, Daniel C., Rabizadeh, Shahrooz, Chandra, Sreeganga, Shayya, Rana F., Ellerby, Lisa M., Ye, Xin, Salvesen, Guy S.

Journal:

Nature Medicine

Year:

2000

Language:

english

File:

PDF, 441 KB

english, 2000

29

The Fas–FADD death domain complex structure unravels signalling by receptor clustering

Scott, Fiona L., Stec, Boguslaw, Pop, Cristina, Dobaczewska, Małgorzata K., Lee, JeongEun J., Monosov, Edward, Robinson, Howard, Salvesen, Guy S., Schwarzenbacher, Robert, Riedl, Stefan J.

Journal:

Year:

2008

Language:

english

File:

PDF, 715 KB

english, 2008

30

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

Chekeni, Faraaz B., Elliott, Michael R., Sandilos, Joanna K., Walk, Scott F., Kinchen, Jason M., Lazarowski, Eduardo R., Armstrong, Allison J., Penuela, Silvia, Laird, Dale W., Salvesen, Guy S.

Journal:

Year:

2010

Language:

english

File:

PDF, 893 KB

english, 2010

31

Small molecules not direct activators of caspases

Denault, Jean-Bernard, Drag, Marcin, Salvesen, Guy S, Alves, Juliano, Heidt, Analeah B, Deveraux, Quinn, Harris, Jennifer L

Journal:

Nature Chemical Biology

Year:

2007

Language:

english

File:

PDF, 2.68 MB

english, 2007

32

Proteolytic needles in the cellular haystack

Enoksson, Mari, Salvesen, Guy S

Journal:

Nature Chemical Biology

Year:

2008

Language:

english

File:

PDF, 296 KB

english, 2008

33

Activity-based probes that target diverse cysteine protease families

Kato, Daisuke, Boatright, Kelly M, Berger, Alicia B, Nazif, Tamim, Blum, Galia, Ryan, Ciara, Chehade, Kareem A H, Salvesen, Guy S, Bogyo, Matthew

Journal:

Nature Chemical Biology

Year:

2005

Language:

english

File:

PDF, 344 KB

english, 2005

34

Apoptosis: IAP proteins: blocking the road to death's door

Salvesen, Guy S., Duckett, Colin S.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2002

Language:

english

File:

PDF, 1.17 MB

english, 2002

35

Structural and kinetic determinants of protease substrates

Timmer, John C, Zhu, Wenhong, Pop, Cristina, Regan, Tim, Snipas, Scott J, Eroshkin, Alexey M, Riedl, Stefan J, Salvesen, Guy S

Journal:

Nature Structural and Molecular Biology

Year:

2009

Language:

english

File:

PDF, 1.20 MB

english, 2009

36

Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death

Amarante-Mendes, Gustavo P, Finucane, Deborah M, Martin, Seamus J, Cotter, Thomas G, Salvesen, Guy S, Green, Douglas R

Journal:

Cell Death & Differentiation

Year:

1998

Language:

english

File:

PDF, 457 KB

english, 1998

37

Investigation of glucocorticoid-induced apoptotic pathway: Processing of Caspase-6 but not Caspase-3

Miyashita, Toshiyuki, Nagao, Kazuaki, Krajewski, Stanislaw, Salvesen, Guy S, Reed, John C, Inoue, Tadashi, Yamada, Masao

Journal:

Cell Death & Differentiation

Year:

1998

Language:

english

File:

PDF, 280 KB

english, 1998

38

Caspases: opening the boxes and interpreting the arrows

Salvesen, Guy S

Journal:

Cell Death & Differentiation

Year:

2002

Language:

english

File:

PDF, 80 KB

english, 2002

39

XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs

Scott, Fiona L, Denault, Jean-Bernard, Riedl, Stefan J, Shin, Hwain, Renatus, Martin, Salvesen, Guy S

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 296 KB

english, 2005

40

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

Eckelman, Brendan P, Salvesen, Guy S, Scott, Fiona L

Journal:

Year:

2006

Language:

english

File:

PDF, 331 KB

english, 2006

41

Caspase activation – stepping on the gas or releasing the brakes? Lessons from humans and flies

Salvesen, Guy S, Abrams, John M

Journal:

Year:

2004

Language:

english

File:

PDF, 212 KB

english, 2004

42

Endogenous Inhibitors of Caspases

Quinn L. Deveraux, Henning R. Stennicke, Guy S. Salvesen, John C. Reed

Journal:

Journal of Clinical Immunology

Year:

1999

Language:

english

File:

PDF, 1.40 MB

english, 1999

43

Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3

Chengbiao Lu, Weiming Fu, Guy S. Salvesen, Mark P. Mattson

Journal:

NeuroMolecular Medicine

Year:

2002

Language:

english

File:

PDF, 190 KB

english, 2002

44

Mechanisms of caspase activation

Kelly M Boatright, Guy S Salvesen

Journal:

Current Opinion in Cell Biology

Year:

2003

Language:

english

File:

PDF, 368 KB

english, 2003

45

Divide and die another day

Frank Uhlmann, Guy Salvesen

Journal:

Current Opinion in Cell Biology

Year:

2010

Language:

english

File:

PDF, 86 KB

english, 2010

46

An Optimized Activity-Based Probe for the Study of Caspase-6 Activation

Laura E. Edgington, Bram J. van Raam, Martijn Verdoes, Christoph Wierschem, Guy S. Salvesen, Matthew Bogyo

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 1.55 MB

english, 2012

47

Caspase Inhibition, Specifically

Guy S. Salvesen, Stefan J. Riedl

Journal:

Year:

2007

Language:

english

File:

PDF, 63 KB

english, 2007

48

Properties of the caspases

Henning R. Stennicke, Guy S. Salvesen

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1998

Language:

english

File:

PDF, 1.03 MB

english, 1998

49

Caspases – controlling intracellular signals by protease zymogen activation

Henning R. Stennicke, Guy S. Salvesen

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

2000

Language:

english

File:

PDF, 404 KB

english, 2000

50

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

Domagoj Vucic, Henning R. Stennicke, Maria Teresa Pisabarro, Guy S. Salvesen, Vishva M. Dixit

Journal:

Current Biology

Year:

2000

Language:

english

File:

PDF, 373 KB

english, 2000

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